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Mal-Acetyl-Beta-Ala-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan deuterium-labeled-carboxylic ester 548Ex/562Em) is a sulfonated derivative

SKU 59504262622
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Description

548Ex/562Em) is a sulfonated derivative of the Cy3 dye

Product Name: 5(6)-FAM PEG3 azide Synonyms: 5-(and 6)-Carboxyfluorescein-PEG3-Azide CAS Number: N/A Molecular Formula: C29H28N4O9 Molecular Weight: 576

214 Purity (HPLC) >= 95% Solubility DMSO

The red-fluorescent Lissamine rhodamine B C2 maleimide is a thiol reactive dye

6 SMILES [H][C@]12CS[C@@H](CCCCC(=O)NCCOCCOCCOCCOCCC(O)=O)[C@@]1([H])NC(=O)N2 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Mal-Acetyl-Beta-Ala-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan deuterium-labeled-carboxylic ester 548Ex/562Em) is a sulfonated derivativeSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker

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